Benzodiazepine receptor: Heterogeneity in rabbit brain |
| |
Authors: | Isao Yokoi Susan E Rose Takehiko Yanagihara |
| |
Institution: | Department of Neurology, Mayo Clinic and Mayo Medical School, Rochester, MN 55901, USA |
| |
Abstract: | Binding characteristics of benzodiazepine receptors were studied with synaptosomal and microsomal membranes from rabbit brain utilizing methyl-3H]diazepam. In synaptosomal membranes, both high and low affinity binding sites were identified with the dissociation constants (Kd) of 4.92 nM and 83.8 nM, respectively. However, only the high affinity site was identified with Kd of 3.96 nM with microsomal membranes. Benzodiazepine binding sites appear to include at least two subpopulations of receptors, one with high affinity and another with low affinity binding site. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|