Normal cortical concentration of cholecystokinin-like immunoreactivity with reduced choline acetyltransferase activity in senile dementia of Alzheimer type |
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| Authors: | MN Rossor JF Rehfeld PC Emson CQ Mountjoy M Roth LL Iversen |
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| Institution: | 77. Departments of Neurological Surgery & Neurology, USA;71. Psychiatry, Addenbrooke''s Hospital, Hills Road, Cambridge, USA;1. Institute of Medical Biochemistry, University of Aarhus, DK-8000 Arhus C, Denmark;7. MRC Neurochemical Pharmacology Unit, Medical Research Council Centre, Medical School, Hills Road, Cambridge, USA |
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| Abstract: | Choline acetyltransferase (ChAT) activity and cholecystokinin immunoreactivity (CCK-I) were determined in ten brains from patients dying with a diagnosis of senile dementia of Alzheimer type (SDAT) and in ten brains from control cases. The post-mortem stability of CCK-I was high, as determined using a mouse brain model. Although ChAT activity was significantly reduced in the cerebral cortex, hippocampus and caudate nucleus in the SDAT cases, there was no difference in CCK-I content between the two groups in any brain area. Thus the population of intrinsic cortical cells which contains CCK-I does not appear to be significantly affected in SDAT. |
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