Specific binding of 77Br--bromospiroperidol in rat brain: A potential tool for gamma ray imaging |
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Authors: | H.K. Kulmala C.C. Huang R.J. Dinerstein A.M. Friedman |
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Affiliation: | 1. Department of Pharmacological and Physiological Sciences, and Department of Radiology, The University of Chicago, Chicago, Illinois 60637, U.S.A.;2. Chemistry Division, Argonne National Laboratory, Argonne, Illinois 60439, U.S.A. |
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Abstract: | The binding of the gamma labeled neuroleptic, 77Br--bromosprioperidol, in the rat brain was examined . This binding parallels the binding of 3H-spiroperidol, in that binding is especially high in dopaminergically innervated areas, is saturable, and is displaced by high doses of unlabeled spiroperidol (1–5). Thus, 77Br--bromospiroperidol is a suitable ligand for use in gamma ray imaging techniques for monitoring of receptor binding. |
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Keywords: | To whom correspondence should be addressed at: Department of Pharmacological and Physiological Sciences The University of Chicago Chicago IL 60637 USA. |
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