Chronic intravenous infusion of noradrenaline produces labile hypertension in conscious rats |
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Authors: | J. Kleinjans C. Kasbergen L. Vervoort-Peters J. Smits H.A.J. Struyker Boudier |
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Affiliation: | Department of Pharmacology University of Limburg P.O. Box 616, 6200 MD Maastricht The Netherlands |
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Abstract: | Nonadrenaline was infused intravenously for 5 days into conscious, unrestrained normotensive rats. Infusion of 40 μg per kg body weight per hour caused a chronic elevation of blood pressure, reaching a maximum increase of 28 ± 5 mm Hg on the fifth day. This hypertension is characterized by a labile blood pressure: periods of normotension are followed by rapid outbursts of hypertension. Resting plasma levels of noradrenaline ranged from 0.20–1.25 ng/ml. Infusion of 40 μg per kg body weight per hour caused a 4–5 fold increase. These observations suggest that chronic elevations of plasma noradrenaline are associated with labile hypertension. |
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