Radioimmunoassay of haloperidol in human serum: Correlation of serum haloperidol with serum prolactin |
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Authors: | Russell E Poland Robert T Rubin |
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Institution: | Department of Psychiatry, Harbor-U.C.L.A. Medical Center, Torrance, CA 90509 USA |
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Abstract: | A radioimmunoassay (RIA) for measurement of serum haloperidol is described. Compared to gaschromatography (GC), RIA values average 40% higher. However, a simple organic extraction of serum yields statistically equivalent RIA and GC haloperidol determinations. For both men and women combined, there was a positive correlation between dose (mg/kg/day) and steady-state serum haloperidol level (r = +0.86) and between steady-state serum haloperidol and serum prolactin (PRL) concentration (r = +0.87). |
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