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Effect of lyso-phosphatidylserine on rat hypothalamic cAMP, in vivo
Authors:G. Calderini  S. Teolato  A.C. Bonetti  A. Battistella  G. Toffano
Affiliation:Fidia Research Laboratories, Dept. of Biochemistry, Abano Terme, Italy
Abstract:Lyso-Phosphatidylserine, like its precursor phosphatidylserine, increases the concentration of cAMP in the rat hypothalamus. The effect is dose-dependent and reaches its maximum 10–20 minutes from the injection. Antiadrenergic drugs, such as reserpine, α-methyl-p-tyrosine (α-MpT), haloperidol and chlorpromazine, but not phentolamine or propranolol, prevent the accumulation of hypothalamic cAMP induced by lysophosphati dylserine. Serotoninergic, histaminergic, cholinergic and GABAergic drugs do not modify the lyso-phosphatidylserine effect. The obtained results suggest a primary involvement of the dopaminergic system in the mediation of the pharmacological effect of lyso-phosphatidylserine.
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