Intracranial self-administration of morphine into the ventral tegmental area in rats |
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Authors: | Michael A Bozarth Roy A Wise |
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Institution: | Center for Research on Drug Dependence Department of Psychology Concordia University Montreal, Quebec H3G 1M8, Canada |
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Abstract: | The rewarding properties of morphine injected directly into the ventral tegmental area were investigated using a self-administration procedure. Experimentally naive rats demonstrated rapid acquisition of a lever-pressing response which produced a 100 ng infusion of morphine sulfate solution. Response rates were relatively stable and markedly exceeded lever-press rates of rats passively receiving the same pattern of infusions (i.e., yoked control procedure). Intracranial self-administration was effectively blocked by naloxone suggesting that this behavior is mediated through opiate receptors and is not the consequence of mechanical trauma, or changes in osmolarity or pH. |
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