Effects of narcotic antagonists on L-dopa reversal of reserpine-induced catalepsy and blepharoptosis in mice |
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Authors: | Mike M Namba Raymond M Quock Marvin H Malone |
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Institution: | 7. Physiology-Pharmacology Unit, School of Pharmacy, University of the Pacific, Stockton, California 95211, USA;1. Department of Basic Sciences, School of Dentistry, Marquette University, 604 North 16th St., Milwaukee, Wisconsin 53233, USA |
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Abstract: | Reserpine (1 mg/kg, i.p.) induced catalepsy and blepharoptosis in mice which were readily reversed by the administration of L-dopa (300 mg/kg, i.p.). The administration of the pure narcotic antagonists naloxone (10 mg/kg, i.p.) and naltrexone (1 mg/kg, i.p.) significantly potentiated L-dopa reversal of reserpine-induced catalepsy. Lower doses of the narcotic antagonists did not significantly alter this reversal. The L-dopa reversal of blepharoptosis was not significantly altered by either naloxone or naltrexone. These results indicate that while opiate receptors may be involved in L-dopa reversal of catalepsy, they may not have a role in the alteration of blepharoptosis. |
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