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Chronic d-amphetamine in nucleus accumbens: Lack of tolerance or reverse tolerance of locomotor activity
Authors:George G. Dougherty  Everett H. Ellinwood
Affiliation:Behavioral Neuropharmacology Laboratory Department of Psychiatry Duke University Medical Center Durham, North Carolina 27710, USA
Abstract:An experiment was designed to test the ability of chronic intra-accumbens amphetamine injections to produce the augmentation of locomotor activity noted with repeated intraperitoneal injections. Results revealed increased response variability with chronic injections; but no augmentation or tolerance occurred, in spite of preservation of a dose dependent locomotor response to amphetamine in the nucleus accumbens.
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