The prolactin response to intravenous dextroamphetamine in normal young men and postmenopausal women |
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Authors: | Uriel Halbreich Edward J Sachar Gregory M Asnis R Swami Nathan Frieda S Halpern |
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Institution: | New York State Psychiatric Institute and Department of Psychiatry College of Physicians and Surgeons of Columbia University 722 West 168th Street, New York, New York 10032, USA |
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Abstract: | D-amphetamine was administered intravenously in doses of 0.1 mg/kg and 0.15 mg/kg to normal young men and postmenopausal women in both morning and evening. No suppression of PRL secretion after amphetamine was found, and, in the postmenopausal women, no significant change in PRL levels in any dose or time condition occured. However, a significant and relatively consistent PRL release was induced in the young men in the evening by the higher dose. This latter response suggests that, in humans, dextroamphetamine can actually stimulate prolactin perhaps by a mechanism other than alteration in dopaminergic tone. |
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