Bombesin-like peptides in rat spinal cord: Biochemical characterization,localization and mechanism of release |
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| Authors: | Terry W Moody Nguyen B Thoa Thomas L O&#x;Donohue David M Jacobowitz |
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| Institution: | 1. Department of Biochemistry, The George Washington University, School of Medicine and Health Sciences, Washington, D.C. 20037, USA;2. Department of Anesthesiology, Uniformed Services University of Health Sciences, Bethesda, MD 20014, USA;3. Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20205, USA |
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| Abstract: | Bombesin-like peptides were characterized in rat spinal cord by radio-immunoassay. The density of bombesin-like peptides was eight-fold greater in the dorsal than ventral horn or white matter of the spinal cord. Using high pressure liquid chromatography fractionation techniques, the main peak of immunoreactivity coeluted with synthetic bombesin. Also, the mechanism of release spinal cord peptides was determined. K+ and veratridine stimulated release of immunoreactive bombesin in a Ca++-dependent mechanism. These data indicate that bombesin-like peptides may function as a unique class of neuroregulatory agents in mammalian spinal cord. |
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| Keywords: | To whom all correspondence should be addressed |
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