Activities of ornithine aminotransferase and ornithine decarboxylase in chronically uremic rats |
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| Authors: | Marian Wang Iris Schutz Joel Kopple Marian Swendseid |
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| Affiliation: | 1. From the Schools of Public Health and Medicine, University of California, Los Angeles, USA;2. Research and Medical Services Veterans Administration Wadsworth Hospital Center, Los Angeles, California 90024, USA |
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| Abstract: | The activities of two enzymes mediating different pathways of ornithine catabolism were measured in liver and kidney of chronically uremic rats and their pair-fed controls. Two months following partial nephrectomy hepatic ornithine aminotransferase (OAT) activity tended to be lower in uremic rats and was correlated with urea clearance and with carbamoyl phosphate synthetase activity. Renal OAT activity in uremic rats was also correlated with urea clearance. When uremic rats were maintained for five months, OAT activity was significantly decreased in liver but not in kidney and the activity of ornithine decarboxylase (ODC), the enzyme regulating polyamine biosynthesis, was reduced in both liver and kidney. In cross-over experiments, evidence was obtained for a factor in uremic kidney cytosol which inhibited renal ODC activity. |
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