Heroin reward is dependent on a dopaminergic substrate |
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| Authors: | Michael A. Bozarth Roy A. Wise |
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| Affiliation: | Center for Research on Drug Dependence Department of Psychology Concordia University Montreal, Quebec H3G 1M8, Canada |
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| Abstract: | The rewarding property of heroin was blocked by pretreatment with either naloxone or pimozide, suggesting that this opiate-receptor mediated effect is dependent on a dopaminergic substrate. The involvement of a dopaminergic mechanism in this effect supports the notion that opiates and other sources of reward activate a similar neural substrate. |
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