| 细胞受体介导的疱疹病毒侵入机制 |
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| 引用本文： | 尹彩霞,于少雄,仇华吉. 细胞受体介导的疱疹病毒侵入机制[J]. 微生物学报, 2018, 58(1): 1-9 |
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| 作者姓名： | 尹彩霞 于少雄 仇华吉 |
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| 作者单位： | 中国农业科学院哈尔滨兽医研究所, 兽医生物技术国家重点实验室, 黑龙江 哈尔滨 150069;长江大学动物科学学院, 湖北 荆州 434025,中国农业科学院哈尔滨兽医研究所, 兽医生物技术国家重点实验室, 黑龙江 哈尔滨 150069,中国农业科学院哈尔滨兽医研究所, 兽医生物技术国家重点实验室, 黑龙江 哈尔滨 150069 |
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| 基金项目： | 国家自然科学基金（31672537，31570149） |
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| 摘 要： | 疱疹病毒(Herpesviruses)是一类较大的双链DNA囊膜病毒,广泛感染人和多种动物,以皮肤、粘膜和神经组织的疱疹性病变为特征。病毒侵入宿主细胞为整个复制周期的首要环节,而受体是介导病毒吸附、内化以及膜融合等侵入过程的关键宿主因子。因此,对受体的研究已经成为了解病毒侵入机制以及开发抗病毒制剂的突破口。本综述介绍了与疱疹病毒侵入相关的受体分子以及在这些分子介导下的跨膜机制,同时讨论了目前疱疹病毒侵入方面仍存在的问题和未来的研究方向。
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| 关 键 词： | 疱疹病毒 囊膜蛋白 细胞受体 侵入 膜融合 内吞 |
| 收稿时间： | 2017-01-25 |
| 修稿时间： | 2017-04-08 |
Cellular receptors-mediated invasion of herpesviruses |
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| Caixia Yin,Shaoxiong Yu and Huaji Qiu. Cellular receptors-mediated invasion of herpesviruses[J]. Acta microbiologica Sinica, 2018, 58(1): 1-9 |
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| Authors: | Caixia Yin Shaoxiong Yu Huaji Qiu |
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| Affiliation: | State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, Heilongjiang Province, China;College of Animal Sciences, Yangtze University, Jingzhou 434025, Hubei Province, China,State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, Heilongjiang Province, China and State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, Heilongjiang Province, China |
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| Abstract: | Herpesviruses are a group of enveloped, double-stranded DNA viruses that can infect human and various animals, and induce herpes lesions in skin, mucous membranes and nerve tissues. Their invasion into host cells is the initial step in the virus life cycle, and receptors are the important host factors that mediate virus invasion, including attachment, internalization and membrane fusion. Therefore, to study receptors is important to understand viral invasion and to develop antivirals. We review here the cellular receptors and their mediation of membrane translocation. Current problems and future research needs are also discussed. |
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| Keywords: | herpesviruses envelope proteins cellular receptors entry membrane fusion endocytosis |
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