|
|||||
|
|
Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics |
|
| Authors: | Yonghui Zhang Xiaojing Lin Fengwei Zhang Jia Wu Wenjie Tan Jianfang Zhou Yue Wang |
| Institution: | a State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Yingxin Street 100, Xuanwu District, Beijing 100052, PR China b Institute of Pathogens and Vectors, Dali University, Dali 671003, Yunnan Province, PR China c Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, PR China |
| Abstract: | The current pandemic influenza A (H1N1) virus has revealed a complicated reassortment of various influenza A viruses. The biological study of these viruses, especially of the viral envelope proteins hemagglutinin (HA) and neuraminidase (NA), is urgently needed for the control and prevention of H1N1 viruses. We have generated H1N1-2009 and H1N1-1918 pseudotyped particles (pp) with high infectivity. Combinations of HA1918 + NA2009 and HA2009 + NA1918 also formed infectious H1N1pps, among which the HA2009 + NA1918 combination resulted in the most highly infectious pp. Our study demonstrated that some reassortments of H1N1 viruses may hold the potential to produce higher infectivity than do their ancestors. |
| Keywords: | Influenza A (H1N1) virus HA hemagglutinin NA neuraminidase H1N1pp H1N1 pseudotyped particle |
| 本文献已被 ScienceDirect 等数据库收录！ | |