Hybribox: a device for processing numbers of radioactively labeled hybridization filters with a minimum of personal exposure

The device described permits the rapid and efficient processing of large numbers of filter hybridizations while virtually eliminating exposure to radioactive emission from the labeled probe. The filters are annealed and washed without being transferred from the holder. Throughout the process, the Plexiglas composition of the device absorbs the beta particles and exposure to the hands and arms is essentially zero. Since the hybridization solution can be reused several times, the cost involved approximates that of the conventional methods for hybridization.