Circulating kisspeptin levels exhibit sexual dimorphism in adults, are increased in obese prepubertal girls and do not suffer modifications in girls with idiopathic central precocious puberty |
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Authors: | Pita Jimena Barrios Vicente Gavela-Pérez Teresa Martos-Moreno Gabriel Á Muñoz-Calvo María T Pozo Jesús Rovira Adela Argente Jesús Soriano-Guillén Leandro |
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Institution: | a Laboratory of Endocrinology, Institute of Biomedical Research-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain b Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Institute of Biomedical Research-La Princesa, Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain c CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain d Pediatric Endocrinology Unit, Institute of Biomedical Research-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain e Department of Endocrinology, Institute of Biomedical Research-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain |
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Abstract: | The system KISS1-KISS1R is one of the main regulators of the hypothalamic-pituitary-gonadal axis and constitutes a link between metabolism and reproduction through its interaction with leptin. The aim of this study was to clarify the possible utility of kisspeptin as a pubertal marker and/or the possible influence of nutritional status in kisspeptin levels. To this end, we have studied kisspeptin plasma levels throughout sexual development and in prepubertal obese girls and girls affected by idiopathic central precocious puberty (CPP). Plasma kisspeptin concentrations were analyzed by RIA. An increase in kisspeptin levels was observed in adult females compared to healthy prepubertal and pubertal girls (p < 0.001) and to adult males (p < 0.001). Additionally, kisspeptin was increased in prepubertal obese girls compared to healthy prepubertal girls (p < 0.01) and girls with idiopathic CPP (p < 0.05). As revealed by the regression analysis, in prepubertal healthy and obese girls and girls with idiopathic CCP, the parameters that influenced kisspeptin levels were BMI (R2 = 0.10, p < 0.05) and leptin levels (R2 = 0.14, p < 0.01). In conclusion, kisspeptin levels do not seem to be a good pubertal marker. The results obtained in prepubertal and idiopathic CCP girls point to a relationship between leptin, BMI and kisspeptin at least in this group, and suggest a possible role for adipose tissue in the modulation kisspeptin synthesis. |
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Keywords: | Kisspeptin Leptin Obesity Central precocious puberty |
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