Mitodepressive effects ofChelidonium alkaloids on root tip cells ofAllium cepa L |
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Authors: | Anna Krahulcová |
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Institution: | (1) Research Institute of Child Development, Faculty of Pediatrics, Charles University, V úvalu 84, 150 06 Praha 5, Czechoslovakia;(2) Present address: U garází 4, 170 00 Praha 7, Czechoslovakia |
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Abstract: | A comparison of the effects of a water extract of the fresh vegetation apex ofChelidonium majus L. var.majus, with those of berberine sulphate and of chelidonine hydrochloride is reported. The water extract of fresh stems and leaves
ofChelidonium majus and the berberine sulphate solution had marked mitodepressive effects on onion root tip cells. Chelidonine hydrochloride
had similar but less marked effects. On the basis of the results obtained it can be assumed that the most active group of
substances with cytostatic effects, hindering the cells from entering mitosis, are protoberberine bases contained in the latex
ofChelidonium majus. Within the range of the investigated concentrations the extract of fresh stems and leaves was less toxic for the cells than
berberine sulphate. The data ascertained provide evidence that the mechanism of the cytostatic action of chelidonine, of berberine,
as well as of the extract of fresh stems and leaves ofChelidonium, majus differs from the mechanism of the action of colchicine. Of the testedChelidonium alkaloids only chelidonine produced a partial inactivation of the mitotic spindle. |
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