Both leptin and leptin-receptor are essential for apolipoprotein M expression in vivo |
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Authors: | Xu Ning Nilsson-Ehle Peter Hurtig Maria Ahrén Bo |
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Institution: | Department of Clinical Chemistry, Institute of Laboratory Medicine, University Hospital of Lund, S-221 85 Lund, Sweden. ning.xu@klinkem.lu.se |
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Abstract: | It was previously shown that circulating levels of leptin and apolipoprotein M (apoM) correlate to each other. In this study, we examined whether plasma leptin and leptin-receptors are of importance for apoM expression in vivo. It was found that in both liver and kidney, expression of apoM was significantly lower in leptin deficient ob/ob mice and in leptin-receptor deficient db/db mice than in control mice. Furthermore, leptin administration (0.5 or 1.5 microg/g body weight) significantly increased plasma apoM levels and apoM mRNA levels in liver and in kidney in ob/ob mice. We conclude that both leptin and leptin-receptor are essential for the apoM expression, indicating that leptin is physiologically regulating apoM synthesis in vivo. |
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Keywords: | Apolipoprotein M Leptin Liver Kidney ob/ob mouse db/db mouse |
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