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Surface-core correlations in serum lipoproteins |
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| Authors: | J. N. Herak Greta Pifat Jasminka Brnjas-Kraljević Gabriele Knipping G. Jürgens |
| Affiliation: | (1) Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia, Yugoslavia;(2) Rudjer Bo!["scaron"]("/content/g3k4w66mv76n4704/xlarge353.gif") kovi!["cacute"]("/content/g3k4w66mv76n4704/xlarge263.gif") Institute, University of Zagreb, Zagreb, Croatia, Yugoslavia;(3) Faculty of Medicine, University of Zagreb, Zagreb, Croatia, Yugoslavia;(4) Institute of Medical Biochemistry, University of Graz, Graz, Austria |
| Abstract: | It has been found that the capacity of lipoproteins for binding Mn(II) ions is dependent on the arrangement of the Iipoprotein core. A change in the molecular organization of the LDL core (thermotropic transition) is associated with the change on the lipoprotein surface. In HDL there is no thermotropic transition and no abrupt change of the binding capacity.. The observed surface-core correlation might be an important link in understanding how dietary fat influences the lipoprotein metabolism. |
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