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Discovery of a novel bicycloproline P2 bearing peptidyl alpha-ketoamide LY514962 as HCV protease inhibitor |
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| Authors: | Yip Yvonne Victor Frantz Lamar Jason Johnson Robert Wang Q May Barket Donna Glass John Jin Ling Liu Lifei Venable Daryl Wakulchik Mark Xie Congping Heinz Beverly Villarreal Elcira Colacino Joe Yumibe Nathan Tebbe Mark Munroe John Chen Shu-Hui |
| Institution: | Lilly Research Laboratory, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. |
| Abstract: | We describe herein the design, syntheses and evaluation of a number of bicycloproline P2 bearing HCV protease inhibitors endowed with impressive enzyme potency, enzyme selectivity, cellular activity and favorable ADME profiles. |
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| 本文献已被 PubMed 等数据库收录！ | |