Influence of multiplicity of immunizations of children with inactivated influenza vaccine on immune response and the effectiveness of protection |
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Authors: | Slobodniuk A V Romanenko V V Utnitskaia O S Motus T M Pereverzev A V |
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Affiliation: | Urals State Medical Academy, Regional Center of Sanitary and Epidemiological Surveillance, Yekaterinburg, Russia. |
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Abstract: | The formation of immunity and epidemiological effectiveness of inactivated influenza vaccines in children, regularly immunized against influenza for three years, were evaluated. The study revealed that a year after each immunization the number of children having antibodies in liters regarded as protective decreased 2-2.5 times. At the periods of epidemics morbidity rate among the vaccines dynamically decreased in these years 1.3, 2.0 and 2.8 times. Considering that a year after the second immunization a high immune stratum (60-78%) was retained in the group under study, we propose that annual immunization of the same children be limited by a period of three years, followed by an interval of one year. |
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