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w09, a novel autophagy enhancer,induces autophagy-dependent cell apoptosis via activation of the EGFR-mediated RAS-RAF1-MAP2K-MAPK1/3 pathway
Authors:Pinghu Zhang  Zuguo Zheng  Li Ling  Xiaohui Yang  Ni Zhang  Xue Wang
Institution:1. Jiangsu Key Laboratory of New Drug Screening &2. Jiangsu Center for Pharmacodynamics Research and Evaluation &3. National Nanjing Center for Drug Screening &4. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China;5. Institute of Chemical Industry of Forestry Products, CAF, National Engineering Laboratory for Biomass Chemical Utilization &6. Key Laboratory of Forest Chemical Engineering, SFA &7. Key Lab. of Biomass Energy and Material, Nanjing, China
Abstract:
Keywords:apoptosis  ATG7  autophagy  EGFR  gastric cancer  LC3  lysosome  RAS-RAF1-MAP2K-MAPK1/3  SQSTM1  w09
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