Glutamoptosis: A new cell death mechanism inhibited by autophagy during nutritional imbalance |
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Authors: | Victor H Villar |
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Institution: | Institut Européen de Chimie et Biologie, ACTION Unit U1218, INSERM and University of Bordeaux, Pessac, France |
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Abstract: | Glutaminolysis plays a critical role in nutrient sufficiency and cell signaling activation in mammalian cells. Unexpectedly, our recent investigations revealed that the unbalanced activation of glutaminolysis during nutritional restriction causes a particular form of apoptotic cell death, that we termed “glutamoptosis.“ We found that the inhibition of autophagy is a key step to allow glutamoptosis-mediated cell death. Thus, autophagy controls glutamoptosis during nutritional imbalance. |
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Keywords: | α-ketoglutarate apoptosis autophagy glutaminolysis MTORC1 SQSTM1/p62 |
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