Persistent efficacy of long-acting moxidectin for control of trichostrongylid infections of sheep |
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| Institution: | 1. School of Veterinary Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Macedonia, Greece;2. Veterinary Faculty, University of Thessaly, P.O. Box 199, 43100 Karditsa, Greece;3. Fort-Dodge Animal Health, Southampton, United Kingdom;1. School of Chemistry and Chemical Engineering, Institute of Physical Chemistry, Lingnan Normal University, Zhanjiang 524048, PR China;2. Department of Chemistry, Zhejiang University, Hangzhou 310028, PR China;1. School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China;2. Institute for Advanced Materials, Jiangsu University, Zhenjiang 212013, Jiangsu, China;1. Sinopec Beijing Research Institute of Chemical Industry, Beijing 100013, China;2. School of Chemistry and Environment, BeiHang University, Beijing 100191, China;1. Department of Materials Science and Technology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;2. Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand;3. Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand;4. Materials Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand |
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| Abstract: | The objective was to evaluate long-acting moxidectin (Cydectin® 2% LA for sheep) against trichostrongylids in sheep. We performed a blocked, parallel, controlled clinical trial. We included 45 ewe-lambs, allocated into treated (n = 30, 1.0 mg moxidectin per kg bw, subcutaneously at base of ear on D 0) or controls (n = 15). Animals had been naturally infected (pre-treatment geometric mean epg counts: 233 and 249, respectively) and throughout the study grazed at the same pasture. Fortnightly, we collected faecal samples and performed established parasitological techniques (epg counts, coprocultures). We used analysis of covariance for post-treatment results, using pre-treatment counts as covariate, treatment as fixed effect, block as random effect. Geometric mean epg counts in treated animals were 0 up to D 112, 1 on D 126, 4 on D 140 and 13 on D 161. Respective figures for controls were 369–820 up to D 140 and 168 on D 161 (p < 0.05). Persistent efficacy (>90%) was 140 d for Teladorsagia, 119 d for Haemonchus and 115 d for Trichostrongylus. This is the first reported clinical trial of efficacy of long-acting moxidectin in sheep in Europe. Cydectin 2% LA was found to be effective against trichostrongylids of sheep. The particularly long persistent efficacy can provide new possibilities in formulating anthelmintic programs for sheep. |
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