| 蛋白质相互作用调控蛋白质核转运及其功能 |
| |
| 引用本文： | 陈斯,王建,杨晓明. 蛋白质相互作用调控蛋白质核转运及其功能[J]. 生命科学, 2008, 20(5): 790-794 |
| |
| 作者姓名： | 陈斯 王建 杨晓明 |
| |
| 作者单位： | 军事医学科学院放射与辐射医学研究所,北京,100850 |
| |
| 基金项目： | 国家高技术研究发展计划(863计划)，国家重点基础研究发展规划(973计划)，国家自然科学基金创新研究群体基金 |
| |
| 摘 要： | 蛋白质的核转运是真核生物细胞内发生的重要过程之一，是一大群蛋白质发挥其功能的前提，与细胞正常功能的维持密切相关。蛋白质的核运输通常采用核受体介导的方式进行。此过程非常复杂，需要多种蛋白质的参与，涉及到大量的蛋白质相互作用。本文将综合近年来本领域取得的进展，就蛋白质相互作用参与蛋白质核转运来调节蛋白质的亚细胞定位，进一步在多方面影响细胞以及生物体生理功能的变化进行阐述。
|
| 关 键 词： | 蛋白质 核转运 相互作用 |
Protein-protein interaction is essential on nuclear transport and function of nuclear located proteins |
| |
| CHEN Si,WANG Jian,YANG Xiao-ming. Protein-protein interaction is essential on nuclear transport and function of nuclear located proteins[J]. Chinese Bulletin of Life Sciences, 2008, 20(5): 790-794 |
| |
| Authors: | CHEN Si WANG Jian YANG Xiao-ming |
| |
| Affiliation: | (Beijing Institute of Radiation Medicine, Beijing 100850, China) |
| |
| Abstract: | Nuclear transport is an important event in eukaryotic cells, which is the key prerequisite for functional proteins and cell viability. Nuclear transport of proteins is always mediated by nuclear import receptors, which is a very complicated process and involves lots of different proteins and protein-protein interactions. This article reviews recent progress in this field within last a few years. We talk about protein sub-cellular translocation regulated by protein-protein interaction involved in nuclear transport, and discuss its impact on cellular physiological functions in distinct aspects. |
| |
| Keywords: | protein nuclear imoort： interaction |
| 本文献已被 维普 万方数据 等数据库收录！ |
