The type III pantothenate kinase encoded by coaX is essential for growth of Bacillus anthracis |
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| Authors: | Paige Carleitta Reid Sean D Hanna Philip C Claiborne Al |
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| Affiliation: | Center for Structural Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. |
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| Abstract: | In Bacillus anthracis, the novel type III pantothenate kinase (PanKBa; encoded by coaX) catalyzes the first committed step in coenzyme A biosynthesis. We have demonstrated by analyzing the growth characteristics of a conditional coaX mutant that PanKBa is an essential enzyme, thus contributing to its validation as a new antimicrobial target. |
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