Smart latexes for bioseparation |
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Authors: | Haruma Kawaguchi Keiji Fujimoto |
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Institution: | (1) Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan |
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Abstract: | Monodisperse, thermosensitive microspheres with sub-micron diameters are used for separation and collection of proteins and
other biomolecules. The thermosensitivity gives the microspheres two valuable features. One is the controllability of affinity
between microsphere and protein with temperature. The quality and quantity of proteins to be adsorbed on the microspheres
can be controlled with temperature. The other feature is reversible control of dispersion stability. Microspheres which have
adsorbed target proteins in the dispersion can be easily recovered by changing temperature.
This revised version was published online in July 2006 with corrections to the Cover Date. |
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Keywords: | coagulation hydrophilicity latex microsphere thermosensitive polymer |
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