| 中国人红细胞PGM(PGM位点1)多态性的等电聚焦电泳研究 |
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| 引用本文： | 党进军,孙志贤,姜国芝.中国人红细胞PGM(PGM位点1)多态性的等电聚焦电泳研究[J].中国生物化学与分子生物学报,1985,1(Z1):111-115. |
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| 作者姓名： | 党进军 孙志贤 姜国芝 |
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| 作者单位： | 军事医学科学院放射医学研究所 北京
(党进军，孙志贤)，军事医学科学院放射医学研究所 北京(姜国芝) |
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| 摘 要： | 用等电聚焦电泳技术对北京地区180人进行红细胞葡萄糖磷酸变位酶(PGM_1)遗传表型的分析鉴定。共检测出九个PGM_1亚型,可能由于检测样本数还不够多,目前尚未检测到PGM_1 2-亚型。根据测定结果,观察了我国人群中PGM_1亚型的分布情况,并计算出决定PGM_1亚型的四个等位基因频率为:PGM~(1+)_10617,PGM~(1-)_1 0.100,PGM~(2+)_1 0.236,PGM~(2-)_10.047。采用等电聚焦电泳可将PGM_1的个体识别能力(DP值)由用普通淀粉胶电泳分型的0.558提高到0.742。结果与世界上其他国家和地区人群相似,PGM_1在我国人群中同样是一个个体识别能力很高的多态性酶类。
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| 关 键 词： | 葡萄糖磷酸变位酶 等电聚焦 同工酶 遗传分型 |
| 收稿时间： | 1985-12-20 |
ISOELECTRIC FOCUSING STUDIES OF THE POLYMORPHISM OF THE RED CELL PHOSPHO GLUCOIMUTASE (PGM LOCUS 1) IN CHINESE |
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| Dang,Jin-jun Sun,Zhi-xian Jian,Guo-zhi.ISOELECTRIC FOCUSING STUDIES OF THE POLYMORPHISM OF THE RED CELL PHOSPHO GLUCOIMUTASE (PGM LOCUS 1) IN CHINESE[J].Chinese Journal of Biochemistry and Molecular Biology,1985,1(Z1):111-115. |
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| Authors: | Dang Jin-jun Sun Zhi-xian Jian Guo-zhi |
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| Institution: | (Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing |
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| Abstract: | Nine subphenotypes of phosphoglucomutase (PGM1) of human RBC were successfully identified by iso-electric focusing. The distribution of PGM1 subtypes among 180 Chinese individuals in Beijing was determinedby this method. The frequencies of the four alleles at the PGM1 locus were: PGM11+0.617, PGM11-0.100,PGM12+0.236, PGM12-0.047. This technique is simple, fast, and very useful in the study on the genetic poly morphism of the isozymes of red blood celis. |
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| Keywords: | isoelectric focusing genetic typing phosphoglucomutase isozyme |
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