| 不同转移表型肺腺癌细胞PI-PLC的比较研究 |
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| 引用本文： | 彭愈生,任丽君,张金龙.不同转移表型肺腺癌细胞PI-PLC的比较研究[J].中国生物化学与分子生物学报,1993,9(2):136-140. |
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| 作者姓名： | 彭愈生 任丽君 张金龙 |
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| 作者单位： | 哈尔滨医科大学肿瘤研究所，哈尔滨医科大学肿瘤研究所，哈尔滨医科大学肿瘤研究所 哈尔滨 150040，哈尔滨 150040，哈尔滨 150040 |
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| 摘 要： | 实验证明钙、磷脂酰乙醇胺(PE)、磷脂酸(PA)及脱氧胆酸钠(DOC)对两种不同转移表型癌细胞磷脂酰肌醇特异的磷脂酶C(PI-PLC)的活性影响有明显差异。高转移性人肺腺癌细胞亚系(Anip_(973))比低或无转移性人肺腺癌细胞系(AGZY_(83-a))腹水型癌细胞PI-PLC活性高2.25—7.1倍。Anip_(1211)细胞培养液PI-PLC活性也大于AGZY_(83-a)。说明不同表型肺腺癌细胞具有不同性质的PI-PLC,且活性变化与转移表型密切相关。
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| 关 键 词： | PI-PLC 转移 肺腺癌细胞 |
| 收稿时间： | 1993-04-20 |
Comparative Studies of the PI-PLC in Human Lung Carcinoma Cell Lines with Different Metastatic Phenotypes |
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| Peng,Yu-sheng Ren,Li-jun Zhang,Jin-long.Comparative Studies of the PI-PLC in Human Lung Carcinoma Cell Lines with Different Metastatic Phenotypes[J].Chinese Journal of Biochemistry and Molecular Biology,1993,9(2):136-140. |
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| Authors: | Peng Yu-sheng Ren Li-jun Zhang Jin-long |
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| Institution: | (Institute of Oncology, Harbin Medical University, Harbin, 150040 |
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| Abstract: | We observed that the PI-PLC activities of the two cell types were aff- ected differently by Ca~(2+), PE, PA,DOC.The activity of PI-PLC is significantly elevated in Anip_(973) in Ascites which was 2. 25—7.1-fold greater than in the AGZY_(83-a) The PI-PLC activity in Anip_(1211) culture medium was greater than that of AGZY_(83-a).These demonstrated that the PI-PLC in Anip_(1211), _(973)differs from that in AGZY_(83-a) and may be related to the molecular basis for the different metastatic potential. |
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| Keywords: | PI-PLC Metastasis Lung adenocarcinoma cell |
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