Oxipurinol and orotic aciduria: effect on the orotidine-5'-monophosphate decarboxylase activity of cultured human fibroblasts |
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| Authors: | R S Krooth G F Lam S Y Chen Kiang |
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| Affiliation: | Department of Human Genetics and Development College of Physicians and Surgeons Columbia University 630 West 168th Street New York, New York 10032 USA |
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| Abstract: | Growth in certain pyrimidines or in oxipurinol, whose respective ribotides inhibit the final enzyme in the synthetic sequence leading to UMP, causes cultured cells to develop similar increases in activity for that enzyme. The increase is independent of the genotype of the cells for the known Mendelian mutations affecting the basal level of enzyme activity. |
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