Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase |
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Authors: | Hendricks K B Wang B Q Schnieders E A Thorner J |
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Affiliation: | Department of Molecular and Cell Biology, University of California, Berkeley 94720-3202, USA. |
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Abstract: | In metazoans, certain calmodulin-related calcium-binding proteins (recoverins, neurocalcins and frequenins) are found at highest levels in excitable cells, but their physiological roles are largely uncharacterized. Here we show that Saccharomyces cerevisiae contains a frequenin homologue, Frq1, and that its target is Pik1, a phosphatidylinositol-4-OH kinase. Frq1 binds to a conserved sequence motif in Pik1 outside Pik1's catalytic domain and stimulates its activity in vitro. N-myristoylated Frq1 may also assist in Pik1 localization. |
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