Maturation of cellular Fe-S proteins: an essential function of mitochondria |
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| Authors: | Lill R Kispal G |
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| Institution: | Institut für Zytobiologie und Zytopathologie der Philipps-Universit?t Marburg, Robert-Koch-Str. 5, 35033 Marburg, Germany. |
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| Abstract: | Iron-sulfur (Fe-S) cluster-containing proteins perform important tasks in catalysis, electron transfer and regulation of gene expression. In eukaryotes, mitochondria are the primary site of cluster formation of most Fe-S proteins. Assembly of the Fe-S clusters is mediated by the iron-sulphate cluster assembly (ISC) machinery consisting of some ten proteins. |
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