Liver transplant: adenosine metabolism and apoptosis |
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Authors: | Carlucci F Marinello E Gerunda G Neri D Rosi F Floccari F Tabucchi A |
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Institution: | Dipartimento di Medicina Interna, Sci. Endocrino-Metaboliche e Biochimica, Università di Siena, Italy. |
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Abstract: | Apoptosis and necrosis coexist in ischemia-reperfusion (I/R) injury following organ transplant. During experimental liver transplant we evidenced a deep alteration in energy and antioxidant status. The activity of purine catabolic enzymes was also altered. Caspase-3 (C-3), protein tyrosine phosphatase (PTP) showed significative alterations that lead to DNA fragmentation. These findings could be of interest in new potential strategy to prevent and treat I/R injury. |
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