Antibacterial activity of (-)-deoxypseudophrynaminol versus its racemate and derivatives |
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Authors: | Dix Andrew V Meseck Carly M Lowe Adam J Mitchell Miguel O |
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Institution: | Department of Chemistry, Henson School of Science and Technology, Salisbury University, Salisbury, MD 21801, USA. |
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Abstract: | (-)-Deoxypseudophrynaminol 1 possesses 43-fold greater antibacterial potency than the racemate toward Staphylococcus aureus, indicating that the (-)-enantiomer is the biologically active isomer in this assay. Comparison of the percent growth inhibition by derivatives of 1 indicates that prenylation of N8 and replacement of N1-methyl by methyl carbamate are detrimental to antibacterial potency. (-)-1 is a promising lead structure for the development of the novel hexahydropyrrolo2,3-b]indole class of antibacterial agents. |
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