The generation and diversification of spinal motor neurons: signals and responses |
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Authors: | Price Stephen R Briscoe James |
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Institution: | Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. ucgaspr@ucl.ac.uk |
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Abstract: | Motor neurons are probably the best characterised neuronal class in the vertebrate central nervous system and have become a paradigm for understanding the mechanisms that control the development of vertebrate neurons. For many investigators working on this problem the chick embryo is the model system of choice and from these studies a picture of the steps involved in motor neuron generation has begun to emerge. These findings suggest that motor neuron generation is shaped by extracellular signals that regulate intrinsic, cell-autonomous determinants at sequential steps during development. The chick embryo has played a prominent role in identifying the sources of these signals, defining their molecular identities and determining the cell intrinsic programs they regulate. |
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Keywords: | Motor neurons Chick Extrinsic factors Intrinsic factors Spinal cord |
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