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Caulerpenyne-colchicine hybrid: synthesis and biological evaluation |
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| Authors: | Bourdron Julien Commeiras Laurent Barbier Pascale Bourgarel-Rey Véronique Pasquier Eddy Vanthuyne Nicolas Hubaud Jean-Claude Peyrot Vincent Parrain Jean-Luc |
| Affiliation: | UMR-CNRS 6178 SymBio, équipe Synthèse par voie Organométallique, Université Paul Cézanne (Aix-Marseille III), Marseille, France. |
| Abstract: | The synthesis of an analog of caulerpenyne having a trimethoxyaryl moiety was achieved in 11% overall yield over 11 steps. Its biological activity has been evaluated as inhibitor of in vitro tubulin polymerization or angiogenesis. |
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