Synthesis of new analogs of 15-ketosterine from ergosterine |
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| Authors: | Misharin A Iu Timofeev V P |
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| Institution: | Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya ul. 10, Moscow, 119992 Russia. |
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| Abstract: | Ergosteryl acetate was converted through three stages into 3 beta-acetoxy-24-methyl-5 alpha-cholesta-8(14),22-diene-15-one in 32% overall yield. The product was transformed to 3 beta-hydroxy-24- methyl-5 alpha-cholesta-8(14),22-diene-15-one, 3 alpha-hydroxy-24-methyl-5 alpha-cholesta-8(14),22-diene-15-one, and 24-methyl-5 alpha-cholesta-8(14),22-diene-3,15-dione. The compounds were characterized by 1H and 13C NMR spectra. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 1; see also http://www.maik.ru. |
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