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Conformational stability of alternating d (CG) oligomers in high salt solution. |
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| Authors: | F Quadrifoglio G Manzini M Vasser K Dinkelspiel and R Crea |
| Abstract: | The conformation of d (CG)n oligomers with n = 2,3 has been studied in aqueous solution in the presence of high salt concentration. A minimum n value of three is necessary to obtain a left-handed Z-helix. When d (CG)3 is flanked by three non Z-helicogenic alternating AT sequences the left-handed helix is unstable and a B-type conformation is obtained also at high salt concentration. |
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