Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles: new selective ligands of the 5-HT(7) receptor |
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| Authors: | Kikuchi Chika Hiranuma Toyokazu Koyama Masao |
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| Affiliation: | Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760Morooka-cho, Kohoku-ku, 222-8567, Yokohama, Japan. chika_kikuchi@meiji.co.jp |
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| Abstract: | The synthesis and the affinity for the 5-HT(7) receptor and other receptors of a novel series of fused-ring tetrahydropyridine derivatives are described. Some of the compounds showed high affinity for the 5-HT(7) receptor. Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles and are potent ligands for the 5-HT(7) receptor, with high selectivity over the 5-HT(2) receptor and other receptors. These compounds should be useful tools for clarifying the biological role of the 5-HT(7) receptor. |
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