Elemental profile of cerebrospinal fluid in patients with Parkinson's disease |
| |
Authors: | Alessandro Alimonti Beatrice Bocca Anna Pino Flavia Ruggieri Giovanni Forte Giuseppe Sancesario |
| |
Institution: | aDepartment of Environment and Primary Prevention, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy bNeuroscience Department, University of Rome “Tor Vergata”, Rome, Italy |
| |
Abstract: | To ascertain the potential role of chemical elements (namely, Al, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Ni, Pb, Sb, Si, Sn, Sr, Tl, V, W, Zn and Zr) as markers in the Parkinson's disease (PD), the elemental concentration of cerebrospinal fluid (CSF) of 42 patients with PD and 20 age-matched controls was assessed. Analyses were performed by Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES) and Sector Field Inductively Coupled Plasma Mass Spectrometry (SF-ICP-MS). Significantly lower levels of Co, Cr, Fe, Pb, Si and Sn were observed in the CSF of PD patients compared with those in controls, with a percentage of depletion up to 50% for Cr and Pb. No such variations were detected for all the other elements. Results suggested that Pb, Cr, Fe were the most suitable elements to distinguish between normality and PD. Different cut-off concentrations for these elements could be tentatively proposed as a predictive tool for the PD condition. |
| |
Keywords: | Cerebrospinal fluid Chemical elements ICP-AES Parkinson's disease SF-ICP-MS |
本文献已被 ScienceDirect 等数据库收录! |
|