Taurine promotes connective tissue growth factor (CTGF) expression in osteoblasts through the ERK signal pathway |
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Authors: | L-Q Yuan Y Lu X-H Luo H Xie X-P Wu E-Y Liao |
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Institution: | (1) Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China |
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Abstract: | Summary. Taurine is found in bone tissue, but its function in skeletal tissue is not fully understood. The present study was undertaken
to investigate regulation of gene expression of connective tissue growth factor (CTGF), and the roles of mitogen-activated
protein kinases (MAPKs) in murine osteoblast MC3T3-E1 cells treated with taurine. Western blot analysis showed taurine stimulated
CTGF protein secretion in a dose- and time-dependent manner. Taurine induced activation of extracellular signal-regulated
kinase (ERK), but not p38 and c-jun N-terminal Kinase (JNK), in osteoblasts. Furthermore, pretreatment of osteoblasts with the ERK inhibitor PD98059 abolished
the taurine-induced CTGF production. These data indicate that taurine induces CTGF secretion in MC3T3-E1 cells mediated by
the ERK pathway, and suggest that osteoblasts are direct targets of taurine. |
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Keywords: | : Taurine – Osteoblast – Connective tissue growth factor – Mitogen-activated protein kinase |
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