Platelet-rich plasma and 1,25(OH)2 vitamin D3 synergistically stimulate osteogenic differentiation of adult human mesenchymal stem cells |
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Authors: | Yong Feng Yuan Sun Weitao Jia Changqing Zhang |
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Institution: | 1. Department of Orthopaedics, The Sixth People’s Hospital, Shanghai Jiaotong University, 600 Yishan Road, Shanghai, 200233, China
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Abstract: | Mesenchymal stem cell proliferation and differentiation are regulated by growth factors and systemic hormones in a concerted manner. We have examined the effects of platelet-rich plasma (PRP) and its interaction with 1,25(OH)2 vitamin D3 1,25(OH)2D3] on the differentiation and proliferation of human mesenchymal stem cells (hMSCs). PRP stimulated cell proliferation in a manner inversely proportional to the dose. Exposure to PRP inhibited hMSC osteogenic differentiation. Co-treatment with PRP and 1,25(OH)2D3, however, synergistically stimulated osteogenic differentiation. Serial co-treatment with PRP and 1,25(OH)2D3 showed that this synergistic effect was due to the modulation of a 1,25(OH)2D3-induced differentiation by PRP rather than vice versa. |
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