Gene Expression,Intron Density,and Splice Site Strength in <Emphasis Type="Italic">Drosophila</Emphasis> and <Emphasis Type="Italic">Caenorhabditis</Emphasis> |
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Authors: | Marie E Fahey Desmond G Higgins |
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Institution: | (1) UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland |
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Abstract: | In this paper we investigate the relationships among intron density (number of introns per kilobase of coding sequence), gene
expression level, and strength of splicing signals in two species: Drosophila melanogaster and Caenorhabditis elegans. We report a negative correlation between intron density and gene expression levels, opposite to the effect previously observed
in human. An increase in splice site strength has been observed in long introns in D. melanogaster. We show this is also true of C. elegans. We also examine the relationship between intron density and splice site strength. There is an increase in splice site strength
as the intron structure becomes less dense. This could suggest that introns are not recognized in isolation but could function
in a cooperative manner to ensure proper splicing. This effect remains if we control for the effects of alternative splicing
on splice site strength.
Reviewing Editor: Dr. Nicolas Galtier |
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Keywords: | Intron content Intron density Gene expression Alternative splicing mRNA splice sites |
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