Hepcidin, interleukin-6 and hematological iron markers in males before and after heart surgery |
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| Authors: | Hoppe Michael Lönnerdal Bo Hossain Bakhtiar Olsson Sigvard Nilsson Folke Lundberg Per-Arne Rödjer Stig Hulthén Lena |
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| Institution: | 1. Department of Clinical Nutrition, Sahlgrenska Academy at Göteborg University, S-405 30 Gothenburg, Sweden;2. Department of Nutrition and Program of International Nutrition, University of California, Davis, CA, USA;3. Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden;4. Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden;5. Clinical Chemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden;6. Department of Hematology and Coagulation, Sahlgrenska University Hospital, Gothenburg, Sweden;1. Molecular Immunogenetics Laboratory and Centre of Excellence for Translational Research in Asthma & Lung Disease, CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India;2. Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA;3. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA;1. Minigene Pharmacy Laboratory, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China;2. Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, National Center for Engineering Research of Veterinary Bio-products, Nanjing 210014, China;3. Department of Biological Engineering, Liaoning Economic Management Cadre Institute, Shenyang 110122, China;4. State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China;5. State Key Laboratory of Reproductive Medicine, Department of Gynecology, Nanjing, Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China;1. Department of Pharmacology, Kagawa University, 1750-1 Miki, Kita, Kagawa, Japan;2. The Second Department of Internal Medicine, Kansai Medical University, Japan;3. Department of Endocrinology and Hypertension, Tokyo Women’s Medical University, Tokyo, Japan;1. Department of Physiology, University of Calcutta, West Bengal, India;2. Department of Chemical Technology, University of Calcutta, West Bengal, India;3. Department of Food and Nutrition, University of Calcutta, West Bengal, India |
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| Abstract: | Anemia of inflammation in patients with acute or chronic acute-phase activation is a common clinical problem. Hepcidin is a peptide shown to be the principal regulator of the absorption and systemic distribution of iron. Main inducers of hepcidin are iron overload, hypoxia and inflammation, where the latter has been linked to hepcidin via increased interleukin-6 (IL-6). This article addresses the impact and time course of postoperative acute-phase reaction in humans following heart surgery on prohepcidin, hepcidin, hematological markers and IL-6 concentrations. Serum concentrations of prohepcidin, hepcidin, IL-6 and hematological iron parameters were studied in five male patients without infection before and after heart surgery. This study, which is the first to report the impact on serum hepcidin and serum prohepcidin concentrations in patients following surgery, clearly demonstrates the induction of hypoferremia due to the postoperative acute-phase reaction. Significant changes were seen for serum iron concentration, transferrin saturation, total iron binding capacity and hemoglobin concentration. A significant increase in ferritin concentration was seen 96-144 h postoperatively. Additionally, there were significant alterations in both serum hepcidin after 96-144 h and serum prohepcidin after 48 h compared with preoperative values. Serum prohepcidin decreased, whereas serum hepcidin increased. In conclusion, changes in serum prohepcidin were followed by an increase in serum hepcidin. This speaks in favor of a chain of action where proteolytic trimming of serum prohepcidin results in increased serum hepcidin. However, hypoferremia appeared prior to the changes in serum prohepcidin and serum hepcidin. |
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