Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains |
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| Authors: | J. S. Bailey L. Grabowski‐Boase B. M. Steffy T. Wiltshire G. A. Churchill L. M. Tarantino |
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| Affiliation: | 1. Genomics Institute of the Novartis Research Foundation, Department of Genetics, San Diego, CA, USA;2. Present address: University of North Carolina, Department of Psychiatry, Chapel Hill, NC, USA;3. Present address: University of North Carolina, Division of Pharmacotherapy and Experimental Therapeutics, Chapel Hill, NC, USA;4. The Jackson Laboratory, Bar Harbor, ME, USA |
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| Abstract: | We carried out a quantitative trait loci (QTL) mapping experiment in two phenotypically similar inbred mouse strains, C57BL/6J and C58/J, using the open‐field assay, a well‐established model of anxiety‐related behavior in rodents. This intercross was initially carried out as a control cross for an ethylnitrosurea mutagenesis mapping study. Surprisingly, although open‐field behavior is similar in the two strains, we identified significant QTL in their F2 progeny. Marker regression identified a locus on Chr 8 having associations with multiple open‐field measures and a significant interaction between loci on Chr 13 and 17. Together, the Chr 8 locus and the interaction effect form the core set of QTL controlling these behaviors with additional loci on Chr 1 and 6 present in a subset of the behaviors. |
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| Keywords: | Anxiety locomotor activation open‐field assay quantitative trait locus |
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