Solution scattering studies of dimeric and tetrameric spectrin |
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Authors: | M.H. Reich Z. Kam H. Eisenberg D. Worcester E. Ungewickell W.B. Gratzer |
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Affiliation: | 1. Polymer Research Department, Weizmann Institute of Science, Rehovot, Israel;2. Institut Laue Langevin, Grenoble, France;3. Medical Research Council, Cell Biophysics Unit, King''s College, Drury Lane, London WC2B 5RL, U.K. |
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Abstract: | The structure of spectrin dimers and tetramers in solution has been examined by light, low-angle X-ray and neutron scattering. The results show a good correspondence between the solution dimensions of these molecules and their appearance in the electron microscope after shadowing. The scattering profiles are not compatible with an extended rod-like character, but reflect the presence of a considerable degree of bending. The radii of gyration of the dimer and tetramer were determined to be 170 and 375 Å and the cross-section radii of gyration 14 and 12.3 Å. respectively. Both are thus long. thin. rather bent molecules, and the tetramer is twice the length of the dimer. |
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Keywords: | Light scattering X-ray scattering: Neutron scattering Spectrin conformation |
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