Electrical excitability of artificial enzyme membranes: III. Hysteresis and oscillations observed with immobilized acetylcholinesterase membranes |
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Authors: | A Friboulet D Thomas |
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Institution: | Laboratoire de Technologie Ercymatique E.R.A. No. 338 du CNRS, Université de Technologie de Compiègne, B.P. 233, 60206 Compiègne, France |
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Abstract: | Experimental evidence for memory and oscillations in artificial acetylcholinesterase membranes is presented. When acetylcholine is injected on one side of an artificial proteinic membrane bearing acetylcholinesterase, a potential difference is recorded as a function of time. The steady-state potential due to the enzyme activity for increasing and decreasing substrate concentrations exhibits a hysteresis loop. The non-linearity of the enzyme reaction coupled with the diffusion constraints cause also some instabilities, such as oscillations of the membrane potential. |
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Keywords: | Excitable membrane Immobilized enzyme Acetylcholinesterase Membrane potential (Oscillation) |
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