Metabolomic biomarkers and novel dietary factors associated with gestational diabetes in China |
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| Authors: | Xuyang Chen Jamie V. de Seymour Ting-Li Han Yinyin Xia Chang Chen Ting Zhang Hua Zhang Philip N. Baker |
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| Affiliation: | 1.Department of Obstetrics and Gynaecology,The First Affiliated Hospital of Chongqing Medical University,Chongqing,China;2.State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality,Chongqing Medical University,Chongqing,China;3.Liggins Institute,The University of Auckland,Auckland,New Zealand;4.School of Public Health and Management,Chongqing Medical University,Chongqing,China;5.Institute of Life Sciences,Chongqing Medical University,Chongqing,China;6.College of Medicine, Biological Sciences and Psychology,University of Leicester,Leicester,UK |
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| Abstract: | IntroductionGestational diabetes mellitus (GDM) is impaired glucose tolerance first recognised during pregnancy; its development is associated with many adverse outcomes. Mechanisms of GDM development are not fully elucidated and few studies have used Chinese participants.ObjectivesThe aim of this study was to investigate the maternal metabolome associated with GDM in a Chinese population, and explore the relationship with maternal diet.MethodsNinety-three participants were recruited at 26–28 weeks’ gestation from Chongqing, China. Maternal urine, serum, and hair metabolomes were analysed using gas and liquid chromatography–mass spectrometry. Dietary intake was assessed using a 96-item food frequency questionnaire.ResultsOf the 1064 metabolites identified, 73 were significantly different between cases and controls ( P? ConclusionThis study provides a comprehensive characterization of the maternal metabolome. The snack-based dietary pattern associated with GDM suggests that timing and frequency of consumption are important factors in the relationship between maternal diet and GDM. |
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