Delayed lethal response to Aspergillus fumigatus infection in sarcoma 180 tumor-bearing mice |
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Authors: | Okawa Yoshio Murata Yoshiko Suzuki Masuko Ito Makoto Hotchi Masao Suzuki Shigeo |
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Institution: | The Second Department of Hygienic Chemistry, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Sendai Aoba-ku, Miyagi, 981-8558 Japan. okawa@tohoku-pharm.ac.jp |
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Abstract: | A longer survival and a decrease in the number of fungal cells in kidneys and brain were observed in groups of mice inoculated with Aspergillus fumigatus conidia 2-3 weeks (especially 3 weeks) after sarcoma 180 tumor transplantation compared to groups of non-tumor-bearing (control) mice inoculated with fungal cells only. The 3-4-week tumor-bearing mice had significantly decreased levels of serum iron and increased levels of unbound iron binding capacity in the serum compared to those of the non-tumor-bearing mice. |
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Keywords: | Tumor-bearing mouse Infection Fungal element in tissue Transferrin Aspergillus fumigatus |
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